The Library: Parkinson School Basics
This is a college-level conversation about the the state of the science. This material was designed to be in-depth coverage of the essential concepts required to successfully navigate this diagnosis and all that comes with it.
Dr. Laurie K Mischley
Questions, Ideas, and Suggestions
For over a decade, I've only treated people with Parkinsonism. In clinic, I found myself repeating the same things in clinic. Instead of writing a book, I created the Online Parkinson School series.
Is is designed to walk the line between education, information, inspiration, and medicine.
It is my opinion that Education is Medicine and that we already have the tools necessary for early detection, prevention, and disease-modification, now we need to learn how to use them.
Education is Medicine
All healthcare providers want their patients to be well-informed. Unfortunately, clinic time is often spent putting out fires and on medication management, with inadequate time available for in-depth conversations about one's capacity for disease-modification.
Parkinson School was designed to be an in-depth, high-level conversation about Parkinson nuts and bolts.
Example Curriculum
- What Everyone Should Be Told at Diagnosis (5:33)
- Dopamine Replacement (3:45)
- Parkinsonism vs. Parkinson's Disease (4:53)
- Symptom Management vs. Disease Progression (4:02)
- Taking Inventory (5:01)
- Tracking Symptoms (3:09)
- Vocabulary (12:10)
- Setting Expectations (3:56)
- Learning from Patients (4:54)
- Community Support & Resources (4:57)
- Building Your Team (5:37)
- Experiments & Research (10:46)
- Nutrition (7:31)
- Mindfulness & Summary (6:30)
- Slides
- New Lecture
- 201: UPDATE & DISCUSSION (80:42)
- 201: Resources
- Quality of Life (5:50)
- Tips & Tricks for Making Levodopa Work Better (4:44)
- Levodopa + Carbidopa (12:19)
- Dopamine Agonists (14:03)
- L-dopa & Dietary Protein (11:31)
- Benefits & Perspective (6:51)
- MAO-B Inhibitors (10:19)
- Treating Dyskinesia (7:49)
- Cognitive Processing (3:03)
- Dopamine Repletion- Summary (2:37)
- Guest Lecture: Mucuna (12:41)
- Slides - OK to download
- Drug-Nutrient Interactions: L-dopa & Iron
- Drug-Nutrient Interactions: MAO-B & St John's Wort/ 5-HTP
- 202: Making Dopamine Last Longer and Work Better (77:46)
- 202: Resources
- 202: Dopamine Decision- Recommended Reading
- Rating Scales & Outcome Measures (11:43)
- Why PD is Difficult to Study (10:12)
- Whole Systems Research (10:00)
- Placebo (7:22)
- Participating in Research (7:22)
- Summary (12:49)
- Animal Research (5:50)
- Introduction & Perspective (5:09)
- Biomarkers (6:08)
- Types of Studies (8:11)
- Slides for Download
- Copy of Rating Scales & Outcome Measures
- Copy of Rating Scales & Outcome Measures
- 203: UPDATE & DISCUSSION (69:00)
- 203 Resources/ Links
- 203 Slides
- Does Diet Matter? (6:28)
- Appreciate, Anticipate, & Inhale (9:36)
- Malnutrition is Common (6:16)
- Nutrient Density (4:41)
- Easily Digestible Foods (5:33)
- Break-Fast (3:14)
- Intermittent Fasting (2:12)
- Fresh is Best (4:00)
- How Important is Organic? (4:21)
- Diet & Family (8:42)
- Impact of Slope Reduction (4:19)
- 204 UPDATE & DISCUSSION (62:32)
- 204 Food Graphics
- Parasites of the Planet (Intro) (6:38)
- Encourage: Fresh Vegetables & Fruit (4:45)
- Encourage: Nuts, Seeds & Oils (4:21)
- Encourage: Non-fried Fish (3:18)
- Encourage: Fresh Herbs & Spices (5:14)
- Wine (3:35)
- Farmer's Markets & Co-ops (1:35)
- What to Eat- Summary (4:12)
- Things to Avoid - Overview (2:10)
- Avoid: Dairy (14:23)
- Avoid: Beef, Pork, & Chicken (8:00)
- Avoid: Fried Foods (6:47)
- Avoid: Soda (5:01)
- Movies to Watch
- Diet & PD Infographic_2020 CAM Care PD
- Why Malnutrition is Common in PD (5:22)
- Course 4 & 5 Slides
- Slides- 1 per page (waste of paper alert!!)
- 205: UPDATE & DISCUSSION (66:31)
- 205- Slides
- Parkinson-PRO Diet-- Point Tracking Page
- Intro: If So, So What? (2:35)
- Intro: Stages of Nutritional Deficiency (3:05)
- Intro: Reference Ranges (5:18)
- Complete Blood Count (CBC) & Thyroid (3:41)
- Homocysteine (16:35)
- F2-isoprostanes (6:27)
- hsCRP (12:36)
- Iron (9:56)
- OmegaCheck (EPA, DHA, AA) (5:16)
- Lithium (7:23)
- Vitamin B-12 (9:44)
- DHEA-S: Hormonal Health (5:42)
- Uric Acid (7:49)
- HbA1c (Blood Sugar) (6:30)
- Summary (3:02)
- Slides
- Mischley Reference Range Cheat Sheet
- 206: LAB UPDATE & DISCUSSION (75:06)
- Mischley Intro: What's in There? (4:00)
- Stomach Acid (3:53)
- Components of the Intestinal Tract (7:03)
- Dr. Evans- Intro (2:54)
- Autonomic Nervous System & the Vagus Nerve (2:06)
- Bowel Habits: What's Normal? (3:05)
- Clinical Symptoms Suggestive of a Problem (4:32)
- Weight Loss (4:43)
- "Leaky Gut" (4:07)
- SIBO- Introduction & Testing (5:13)
- SIBO- Treatment Options (9:34)
- Gastric Acid (7:24)
- Summary (2:59)
- Course 107 Slides
- 207: UPDATE & DISCUSSION with Dr. Evans (58:23)
- 207 Resources
- Intro- Strategy & Essentiality (5:22)
- Choosing Quality Supplements (7:29)
- How To Know if It's Working (9:25)
- Glutathione: Biological Plausibility (10:30)
- Glutathione: Repletion Strategies (9:59)
- Coenzyme Q10 (13:10)
- B-12 (6:34)
- Fish Oil / Omega 3's (5:35)
- Lithium (12:40)
- Vitamin C (9:18)
- Homocysteine-Lowering Supplements (9:57)
- Turmeric/ Curcumin (5:20)
- DHEA (5:09)
- Melatonin (3:40)
- Vitamin D (5:46)
- Summary (5:27)
- Relevant links
- SIM Pharmacy Tour (4:46)
- Probiotics (4:00)
- High-dose Thiamine (3:26)
- Slides
- 208: SUPPLEMENTS UPDATE & DISCUSSION (65:49)
- Mischley Intro (4:08)
- Infographic: More Exercise is Better
- Teri's notes
- Nate Coomer: 5 Tips (12:16)
- Claire McLean: Intro (10:36)
- Claire McLean: Inspiration: Dennis (6:13)
- Claire McLean: Inspiration: Fred (4:24)
- Claire McLean: Inspiration: Ann (3:55)
- Claire McLean: Inspiration: Teri (11:16)
- Claire McLean: Physical Therapy ~ Exercise ~ Activity (17:46)
- Claire McLean: Types of Exercise (8:59)
- Claire McLean: How to Exercise (9:48)
- Claire McLean: Assessments (6:52)
- Claire McLean: Medications + Exercise (7:02)
- Claire McLean: What Time of Day to Exercise (1:52)
- Claire McLean: Exercise + Sleep + Nutrition (3:25)
- Claire McLean: Motivation (6:05)
- Claire McLean: Pain (3:51)
- Claire McLean: Summary (5:53)
- Claire McLean: How Much to Exercise (7:32)
- Claire McLean: Interview with Teri (82:14)
- Becky Farley: Big Picture: How Do We Implement This? (15:08)
- Russ Parker: Personal Trainer & PwP (35:26)
- 209: UPDATE & DISCUSSION (51:34)
- Exercise Advice & Discussion 2022 (113:47)
- Mischley Introduction (6:42)
- Dr. Subramanian: What is Yoga? (18:55)
- Dr. Subramanian: How Can Yoga Help PD? (9:57)
- Dr. Subramanian: Advice for Physicians & Yoga Teachers (13:24)
- Dr. Subramanian: Emphasis on Quality of Life (12:51)
- Peter Lynch- Intro to Yoga & Breath (11:53)
- Peter Lynch: Standing Poses (11:49)
- Peter Lynch: Supine Poses (11:41)
- Peter Lynch: Seated Poses (13:11)
- Dr. Duda: Meditation in PD (13:46)
- Debbie Leung: Qi: Chinese Healing and Movement Arts- Intro (22:52)
- Debbie Leung: Qi: Chinese Healing & Movement Arts- Demo (15:41)
- 210 Mindfulness (10:43)
- 210 The Science Behind Mindfulness (8:33)
- 210 Stress Management (12:26)
- 210 The Power of Perspective (4:56)
- 210 Chanting (6:31)
- 210 Pranayama (Breathing) (24:18)
- 310 Mindfulness UPDATE & DISCUSSION (102:54)
- Laurie Mischley: Personal Experience with Cannabis (11:59)
- Laurie Mischley: Research Experience with Cannabis in PD (8:29)
- Cannabis Manuscripts by Sexton, Mischley, et al.
- Cannabis and PD Tremor
- Self-Administration of Cannabis for Patients with PD
- Michelle Sexton: The Nitty Gritty (16:03)
- Michelle Sexton: Introduction & History (9:20)
- Michelle Sexton: Sleep & Summary (13:14)
- Michelle Sexton: CBD & Tincture Tutorial (10:03)
- Michelle Sexton: Quality of Life Drug (12:31)
- Michelle Sexton: Psychoactivity for Apathy? (12:14)
- Tracy Doerschel: Shopping Tutorial (12:47)
- Tracy Doerschel: Symptom Management (8:20)
- 211: Cannabis: UPDATE & DISCUSSION (61:59)
- 311: Cannabis: UPDATE & DISCUSSION (54:16)
- 311 Slides - available to download
- Specific Needs of Parkinsonism (8:16)
- Which Nutrients & Why? (5:46)
- What Do Humans Need? (9:43)
- Relevant Publications
- Glutathione (39:00)
- Lithium (15:25)
- Vitamin D, Coenzyme Q-10, & Closure (6:05)
- Vitamin B-12 & Folate (8:54)
- Melatonin & Vitamin C (12:18)
- 212: UPDATE & DISCUSSION (62:38)
- 312: UPDATE & DISCUSSION (109:34)
- 312: Handouts
- Introduction- Dr. Indu Subramanian (15:01)
- PD Symptoms That Increase Risk of Loneliness (8:42)
- Social Prescribing, Volunteerism, Sense of Purpose (12:23)
- Financial & Clinical Barriers (14:13)
- Virtual Connections & Beyond (8:45)
- Poster- Friends Matter More than Tremor (2:50)
- 213: Social Health UPDATE & DISCUSSION (57:22)
- Social Health Manuscript
- Book Recommendation
- Parkinson Buddy Programs
- Link to Participate in PD Research
- Introduce yourself!
- 213: Laurie Mischley: Describing, Understanding, Modulating Stress (65:05)
- 213: Course Materials- 1 page handout
- Dana Bjerke: Applicable for All People (21:22)
- Jen Riegle: Clinical Approach (20:46)
- Laurie Mischley: Vulnerability to Environmental Insults (8:20)
- Laurie Mischley: Toxicants (6:45)
- Laurie Mischley: Uranium, Manganese (12:37)
- Laurie Mischley: Iron (7:29)
- Laurie Mischley: Ochratoxin-A, Aspartame; Wrap-up (9:23)
- World Parkinson Congress- Ocratoxin A poster (5:16)
- Slides
- 214: Chris Holder: Environmental Considerations (61:55)
- 214 Relevant Links
- 314: Laurie Mischley: Clinical Observations (10:00)
- 314: Joshua Farahnik: If/ When/ How to "Detox" (60:32)
- Infancy & Imprinting (10:44)
- Fake It Until You Make It (8:13)
- The Malleable Mind (7:46)
- Things That Accelerate Atrophy (9:35)
- Exercise-Induced Neuroplasticity (8:11)
- Nutrition, Summary (9:02)
- 115: Leanna Standish: Neuroscientist's Introduction to Ayahuasca (10:04)
- 115: Leanna Standish: Science & Psychedelics (10:24)
- 115: Leanna Standish: Resisting Aging (8:19)
- 215: Suneil Agarwal: Ketamine Therapty (56:42)
- 315: What Can We Learn from Functional Movement Disorders? (53:58)
- Michele Tagliati: DBS is Not One Thing (21:09)
- Michele Tagliati: What Does DBS Have to Offer? (18:47)
- Michele Tagliati: Not All Centers are Created Equally (10:41)
- Michele Tagliati: Who's Calling the Shots? (9:51)
- Michele Tagliati: DBS Contraindications (8:52)
- Michele Tagliati: What About Focused Ultrasound (FUS)? (14:55)
- Karen "Pinky" Karle: Patient Experience (7:49)
- Daniel Jeanmonod: Nuerosurgeon Perspective on Focused Ultrasound (FUS) (47:47)
- Lena McCullogh- Patient Experience (17:29)
- Alfredo Ruiz- Patient Experience (20:32)
- 216: David Spry: DBS Has Downsides (58:34)
- 316: Ben Stecher: Closed Loop DBS Systems (66:25)
- The Nose Knows (13:05)
- Loss of Smell is a Red Flag (11:55)
- Assessing Severity (8:24)
- Smell Retraining (9:58)
- Start Sniffing! (12:50)
- "Smelling and Tasting" PD: Using Senses to Improve the Knowledge of the Disease
- Olfactory Loss from B12 Deficiency
- 217: Smell UPDATE & DISCUSSION (61:44)
- 317: Smell UPDATE & DISCUSSION (72:39)
- 2022 MDS Conference Updates from Dr. Mischley
- What is apathy? (11:44)
- Impact on Relationships (8:12)
- Assessment (2:25)
- Treatment Suggestions (8:38)
- Botox, Face Yoga, & Wrap-up (10:51)
- Face Yoga- sample videos & classes
- 218: UPDATE & DISCUSSION (59:40)
- 218: Apathy UPDATE & DISCUSSION (12:41)
- MDS 2022 - Madrid, Posters, Connections (7:14)
- PD School Meet-ups in 2023 -- What does the future hold? (36:56)
- Introduction (6:58)
- Melatonin Insufficiency & Repletion (18:45)
- Meds & Bed: How Dopamine Replacement Can Help / Hurt (9:34)
- LIght: An Insult & A Therapuetic (7:04)
- Activity & Exhaustion (6:55)
- Things That Interfere With Sleep (8:30)
- Excellent lecture by Dr. Valerio
- Further Explanation
- 219: Sleep UPDATE & DISCUSSION (86:59)
- Introduction: Kimball Magoni, PhD (6:49)
- Reslience (12:25)
- Internal Locus of Control (5:31)
- Diagnosis & Grief Process (9:06)
- Myths & Mindsets (10:49)
- Countering Negative Thinking (8:49)
- Post-Traumatic Growth (12:42)
- Q & A with Dr. Mischley (12:29)
- Kimball's PRO-PD scores over the past 7 years :)
- Lecture Slides
- 221: Kimball Magoni: UPDATE & DISCUSSION (64:53)
- Requested links - books, Dr. Magoni's website, etc.
- 321: Kimball Magoni: UPDATE & DISCUSSION (74:31)
- Kate Wyman-Chick: Introduction to Cognition in Parkinsonism (3:35)
- Kate Wyman-Chick: Cognitive Domains (12:30)
- Kate Wyman-Chick: What is Neuropsychology? (8:50)
- Kate Wyman-Chick: Cognitive Tips (13:41)
- 222: Laurie Mischley: Cognitive Health (63:26)
- 222: Cognition Discussion Slides
- 322: UPDATE & DISCUSSION (57:53)
- Things to Avoid That Increase Risk (12:08)
- Things Associated with Decreased Risk (11:29)
- Available Screening Tests (17:08)
- Early Non-motor Signs to Be Aware Of (11:12)
- Strategic Living (19:45)
- Introduction (10:26)
- The Pandemic is Already Here (4:49)
- The Parkinson Personality (10:26)
- Ignorance is Not Bliss (6:18)
Included in Parkinson School Membership
In addition to a rich library of resources, we meet live throughout the month to continue the conversation and deepen the community.